2J1W

Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D

2J1W の概要

• エントリーDOI: 10.2210/pdb2j1w/pdb
• 関連するPDBエントリー: 1HU8 1UOL 2BIM 2BIN 2BIO 2BIP 2BIQ 2J1X 2J1Y 2J1Z 2J20 2J21
• 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION (3 entities in total)
• 機能のキーワード: second-site suppressor mutation, disease mutation, nuclear protein, phosphorylation, tumor suppressor, alternative splicing, li-fraumeni syndrome, li- fraumeni syndrome, host-virus interaction, transcription, metal-binding, anti-oncogene, dna-binding, transferase, polymorphism, glycoprotein, zinc, activator, apoptosis, cell cycle, acetylation, p53 dna-binding domain, transcription regulation, superstable mutant, dna-binding protein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49256.40

構造登録者

Joerger, A.C.,Fersht, A.R. (登録日: 2006-08-15, 公開日: 2006-09-20, 最終更新日: 2023-12-13)

• 主引用文献: Joerger, A.C.,Ang, H.C.,Fersht, A.R.; Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.; Proc.Natl.Acad.Sci.USA, 103:15056-, 2006; PubMed: 17015838; DOI: 10.1073/PNAS.0607286103

実験手法

X-RAY DIFFRACTION (1.8 Å)