2J0F

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design

Summary for 2J0F

Entry DOI	10.2210/pdb2j0f/pdb
Related	1UOU
Descriptor	THYMIDINE PHOSPHORYLASE, THYMINE (3 entities in total)
Functional Keywords	htp, chemotaxis, transferase, polymorphism, disease mutation, glycosyltransferase, angiogenesis, growth factor, differentiation, developmental protein, human thymidine phosphorylase
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	4
Total formula weight	200499.86
Authors	El Omari, K.,Bronckaers, A.,Liekens, S.,Perez-Perez, M.J.,Balzarini, J.,Stammers, D.K. (deposition date: 2006-08-02, release date: 2006-10-11, Last modification date: 2023-12-13)
Primary citation	El Omari, K.,Bronckaers, A.,Liekens, S.,Perez-Perez, M.,Balzarini, J.,Stammers, D.K. Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design. Biochem.J., 399:199-, 2006 Cited by PubMed: 16803458 DOI: 10.1042/BJ20060513 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.31 Å)

Structure validation