2J0F

Structural basis for non-competitive product inhibition in human thymidine phosphorylase: implication for drug design

2J0F の概要

• エントリーDOI: 10.2210/pdb2j0f/pdb
• 関連するPDBエントリー: 1UOU
• 分子名称: THYMIDINE PHOSPHORYLASE, THYMINE (3 entities in total)
• 機能のキーワード: htp, chemotaxis, transferase, polymorphism, disease mutation, glycosyltransferase, angiogenesis, growth factor, differentiation, developmental protein, human thymidine phosphorylase
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 200499.86

構造登録者

El Omari, K.,Bronckaers, A.,Liekens, S.,Perez-Perez, M.J.,Balzarini, J.,Stammers, D.K. (登録日: 2006-08-02, 公開日: 2006-10-11, 最終更新日: 2023-12-13)

• 主引用文献: El Omari, K.,Bronckaers, A.,Liekens, S.,Perez-Perez, M.,Balzarini, J.,Stammers, D.K.; Structural Basis for Non-Competitive Product Inhibition in Human Thymidine Phosphorylase: Implications for Drug Design.; Biochem.J., 399:199-, 2006; PubMed: 16803458; DOI: 10.1042/BJ20060513

実験手法

X-RAY DIFFRACTION (2.31 Å)