2IWS

Radicicol analogues bound to the ATP site of HSP90

2IWS の概要

• エントリーDOI: 10.2210/pdb2iws/pdb
• 関連するPDBエントリー: 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWU 2IWX
• 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (5Z)-12-CHLORO-13,15-DIHYDROXY-4,7,8,9-TETRAHYDRO-2-BENZOXACYCLOTRIDECINE-1,10(3H,11H)-DIONE (3 entities in total)
• 機能のキーワード: inhibitor, chaperone, heat shock, atp-binding, multigene family, nucleotide-binding
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24533.34

構造登録者

Roe, S.M.,Prodromou, C.,Pearl, L.H. (登録日: 2006-07-04, 公開日: 2006-11-30, 最終更新日: 2023-12-13)

• 主引用文献: Proisy, N.,Sharp, S.Y.,Boxall, K.,Connelly, S.,Roe, S.M.,Prodromou, C.,Slawin, A.M.Z.,Pearl, L.H.,Workman, P.,Moody, C.J.; Inhibition of Hsp90 with Synthetic Macrolactones: Synthesis and Structural and Biological Evaluation of Ring and Conformational Analogs of Radicicol.; Chem.Biol., 13:1203-, 2006; PubMed: 17114002; DOI: 10.1016/J.CHEMBIOL.2006.09.015

実験手法

X-RAY DIFFRACTION (2.7 Å)