2IWD

Oxacilloyl-acylated MecR1 extracellular antibiotic-sensor domain.

2IWD の概要

• エントリーDOI: 10.2210/pdb2iwd/pdb
• 関連するPDBエントリー: 2IWB 2IWC
• 分子名称: Methicillin resistance mecR1 protein, (2R,4S)-5,5-dimethyl-2-[(1R)-1-{[(5-methyl-3-phenyl-1,2-oxazol-4-yl)carbonyl]amino}-2-oxoethyl]-1,3-thiazolidine-4-carb oxylic acid (3 entities in total)
• 機能のキーワード: bacterial antibiotic resistance, oxacillin, beta-lactamase, mrsa, antibiotic resistance, methicillin resistance, beta-lactamic antibiotics, penicillin-binding protein
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29653.81

構造登録者

Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. (登録日: 2006-06-27, 公開日: 2006-07-03, 最終更新日: 2023-12-13)

• 主引用文献: Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X.; Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance.; J.Mol.Biol., 361:506-, 2006; PubMed: 16846613; DOI: 10.1016/J.JMB.2006.06.046

実験手法

X-RAY DIFFRACTION (2.4 Å)