2IWC

Benzylpenicilloyl-acylated MecR1 extracellular antibiotic-sensor domain.

Summary for 2IWC

Entry DOI	10.2210/pdb2iwc/pdb
Related	2IWB 2IWD
Descriptor	METHICILLIN RESISTANCE MECR1 PROTEIN, OPEN FORM - PENICILLIN G (3 entities in total)
Functional Keywords	bacterial antibiotic resistance, mrsa, beta-lactamase, benzylpenicillin, antibiotic resistance, methicillin resistance, beta-lactamic antibiotics, penicillin-binding protein
Biological source	Staphylococcus aureus subsp. aureus N315
Total number of polymer chains	1
Total formula weight	30564.85
Authors	Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. (deposition date: 2006-06-27, release date: 2006-07-04, Last modification date: 2023-12-13)
Primary citation	Marrero, A.,Mallorqui-Fernandez, G.,Guevara, T.,Garcia-Castellanos, R.,Gomis-Ruth, F.X. Unbound and Acylated Structures of the Mecr1 Extracellular Antibiotic-Sensor Domain Provide Insights Into the Signal-Transduction System that Triggers Methicillin Resistance. J.Mol.Biol., 361:506-, 2006 Cited by PubMed: 16846613 DOI: 10.1016/J.JMB.2006.06.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation