2ITP

Crystal structure of EGFR kinase domain G719S mutation in complex with AEE788

2ITP の概要

• エントリーDOI: 10.2210/pdb2itp/pdb
• 関連するPDBエントリー: 1XKK 2ITN 2ITO 2ITQ 2ITT 2ITU 2ITV 2ITW 2ITX 2ITY 2ITZ
• 分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR PRECURSOR, 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE (3 entities in total)
• 機能のキーワード: receptor, cell cycle, atp-binding, transferase, transmembrane, phosphorylation, disease mutation, polymorphism, glycoprotein, anti-oncogene, nucleotide-binding, alternative splicing, aee788, egfr, g719s, kinase, membrane, tyrosine-protein kinase, epidermal growth factor
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted: P00533
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 37774.74

構造登録者

Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J. (登録日: 2006-05-25, 公開日: 2007-04-03, 最終更新日: 2023-12-13)

• 主引用文献: Yun, C.-H.,Boggon, T.J.,Li, Y.,Woo, S.,Greulich, H.,Meyerson, M.,Eck, M.J.; Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity; Cancer Cell, 11:217-, 2007; PubMed: 17349580; DOI: 10.1016/J.CCR.2006.12.017

実験手法

X-RAY DIFFRACTION (2.74 Å)