Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer

Summary for 2ILM

Related1H2K 1H2L 1H2N 1H2M 1YCI
DescriptorHypoxia-inducible factor 1 alpha inhibitor, Hypoxia-inducible factor 1 alpha, FE (II) ION, ... (8 entities in total)
Functional Keywordsfih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, transcription regulator, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationNucleus (Potential) Q9NWT6
Cytoplasm Q16665
Total number of polymer chains2
Total molecular weight45522.58
Mcdonough, M.A.,Schofield, C.J. (deposition date: 2006-10-03, release date: 2007-08-14, Last modification date: 2011-07-13)
Primary citation
Hewitson, K.S.,Holmes, S.L.,Ehrismann, D.,Hardy, A.P.,Chowdhury, R.,Schofield, C.J.,McDonough, M.A.
Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).
J.Biol.Chem., 283:25971-25978, 2008
PubMed: 18611856 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M804999200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.266110.3%2.7%10.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution