2ILM
Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer
Summary for 2ILM
Entry DOI | 10.2210/pdb2ilm/pdb |
Related | 1H2K 1H2L 1H2M 1H2N 1YCI |
Descriptor | Hypoxia-inducible factor 1 alpha inhibitor, Hypoxia-inducible factor 1 alpha, FE (II) ION, ... (8 entities in total) |
Functional Keywords | fih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, transcription regulator, oxidoreductase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus (Potential): Q9NWT6 Cytoplasm: Q16665 |
Total number of polymer chains | 2 |
Total formula weight | 45522.58 |
Authors | Mcdonough, M.A.,Schofield, C.J. (deposition date: 2006-10-03, release date: 2007-08-14, Last modification date: 2023-08-30) |
Primary citation | Hewitson, K.S.,Holmes, S.L.,Ehrismann, D.,Hardy, A.P.,Chowdhury, R.,Schofield, C.J.,McDonough, M.A. Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH). J.Biol.Chem., 283:25971-25978, 2008 Cited by PubMed: 18611856DOI: 10.1074/jbc.M804999200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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