2ILM
Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Hypoxia-inducible factor 1 alpha inhibitor | polymer | 349 | 40284.3 | 1 | UniProt (Q9NWT6) Pfam (PF13621) | Homo sapiens (human) | Hypoxia-inducible factor asparagine hydroxylase, Factor inhibiting HIF-1, FIH-1 |
| 2 | B (S) | Hypoxia-inducible factor 1 alpha | polymer | 41 | 4506.9 | 1 | UniProt (Q16665) Pfam (PF08778) | HIF-1 alpha, HIF1 alpha, ARNT- interacting protein, Member of PAS protein 1, MOP1 | |
| 3 | C (A) | FE (II) ION | non-polymer | 55.8 | 1 | Chemie (FE2) | |||
| 4 | D, E (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 5 | F (A) | BICARBONATE ION | non-polymer | 61.0 | 1 | Chemie (BCT) | |||
| 6 | G (A) | 2-OXOGLUTARIC ACID | non-polymer | 146.1 | 1 | Chemie (AKG) | |||
| 7 | H, I, J (A) | GLYCEROL | non-polymer | 92.1 | 3 | Chemie (GOL) | |||
| 8 | K, L (A, S) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 1 - 349 (UniProt: Q9NWT6)
| PDB | External Database | Details |
|---|---|---|
| Ala 201 | Asp 201 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44791.2 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 731.4 | |
| All* | Total formula weight | 45522.6 |
