2ILM

Factor Inhibiting HIF-1 Alpha D201A Mutant in Complex with FE(II), Alpha-Ketoglutarate and HIF-1 Alpha 35mer

Summary for 2ILM

• Entry DOI: 10.2210/pdb2ilm/pdb
• Related: 1H2K 1H2L 1H2M 1H2N 1YCI
• Descriptor: Hypoxia-inducible factor 1 alpha inhibitor, Hypoxia-inducible factor 1 alpha, FE (II) ION, ... (8 entities in total)
• Functional Keywords: fih, hif, dsbh, oxygenase, transcription, hypoxia, inhibitor 2-oxoglutarate, asparaginyl hydroxylase, transcription regulator, oxidoreductase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus (Potential): Q9NWT6; Cytoplasm: Q16665
• Total number of polymer chains: 2
• Total formula weight: 45522.58

Authors

Mcdonough, M.A.,Schofield, C.J. (deposition date: 2006-10-03, release date: 2007-08-14, Last modification date: 2023-08-30)

• Primary citation: Hewitson, K.S.,Holmes, S.L.,Ehrismann, D.,Hardy, A.P.,Chowdhury, R.,Schofield, C.J.,McDonough, M.A.; Evidence that two enzyme-derived histidine ligands are sufficient for iron binding and catalysis by factor inhibiting HIF (FIH).; J.Biol.Chem., 283:25971-25978, 2008; PubMed: 18611856; DOI: 10.1074/jbc.M804999200

Experimental method

X-RAY DIFFRACTION (2.3 Å)