2IJ7

Structure of Mycobacterium tuberculosis CYP121 in complex with the antifungal drug fluconazole

Summary for 2IJ7

Entry DOI	10.2210/pdb2ij7/pdb
Related	1IJ5 1N40
Descriptor	Cytochrome P450 121, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total)
Functional Keywords	tuberculosis, cytochrome p450, p450 cyp121, fluconazole, azole drug, oxidoreductase
Biological source	Mycobacterium tuberculosis
Cellular location	Cytoplasm (By similarity): P0A514
Total number of polymer chains	6
Total formula weight	265065.45
Authors	Roujeinikova, A.,Leys, D. (deposition date: 2006-09-29, release date: 2006-11-07, Last modification date: 2023-08-30)
Primary citation	Seward, H.E.,Roujeinikova, A.,McLean, K.J.,Munro, A.W.,Leys, D. Crystal structure of the Mycobacterium tuberculosis P450 CYP121-fluconazole complex reveals new azole drug-P450 binding mode. J.Biol.Chem., 281:39437-39443, 2006 Cited by PubMed: 17028183 DOI: 10.1074/jbc.M607665200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation