2IGX

Achiral, Cheap and Potent Inhibitors of Plasmepsins II

Summary for 2IGX

• Entry DOI: 10.2210/pdb2igx/pdb
• Related: 2BJU 2IGY
• Descriptor: Plasmepsin-2, 5-PENTYL-N-{[4'-(PIPERIDIN-1-YLCARBONYL)BIPHENYL-4-YL]METHYL}-N-[1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL]PYRIDINE-2-CARBOXAMIDE (3 entities in total)
• Functional Keywords: achiral inhibitor, hydrolase
• Biological source: Plasmodium falciparum (malaria parasite P. falciparum)
• Cellular location: Vacuole: P46925
• Total number of polymer chains: 1
• Total formula weight: 37597.59

Authors

Prade, L. (deposition date: 2006-09-25, release date: 2006-11-28, Last modification date: 2024-10-30)

• Primary citation: Boss, C.,Corminboeuf, O.,Grisostomi, C.,Meyer, S.,Jones, A.F.,Prade, L.,Binkert, C.,Fischli, W.,Weller, T.,Bur, D.; Achiral, Cheap, and Potent Inhibitors of Plasmepsins I, II, and IV.; Chemmedchem, 1:1341-1345, 2006; PubMed: 17091526; DOI: 10.1002/cmdc.200600223

Experimental method

X-RAY DIFFRACTION (1.7 Å)