2IE0

Crystal Structure of Isoniazid-resistant I21V Enoyl-ACP(COA) Reductase Mutant Enzyme From MYCOBACTERIUM TUBERCULOSIS in Complex with NADH-INH

Summary for 2IE0

Entry DOI	10.2210/pdb2ie0/pdb
Related	2IDZ 2IEB 2IED
Descriptor	Enoyl-[acyl-carrier-protein] reductase [NADH], ISONICOTINIC-ACETYL-NICOTINAMIDE-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywords	enoyl-acyl carrier protein, isoniazid, inha, oxidoreductase
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	29178.08
Authors	Dias, M.V.B.,Prado, A.M.X.,Vasconceles, I.B.,Fadel, F.,Basso, L.A.,Santos, D.S.,Azevedo Jr., W.F. (deposition date: 2006-09-15, release date: 2007-07-24, Last modification date: 2023-08-30)
Primary citation	Dias, M.V.,Vasconcelos, I.B.,Prado, A.M.,Fadel, V.,Basso, L.A.,de Azevedo, W.F.,Santos, D.S. Crystallographic studies on the binding of isonicotinyl-NAD adduct to wild-type and isoniazid resistant 2-trans-enoyl-ACP (CoA) reductase from Mycobacterium tuberculosis. J.Struct.Biol., 159:369-380, 2007 Cited by PubMed: 17588773 DOI: 10.1016/j.jsb.2007.04.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation