2ID4
The 1.9 A structure of Kex2 in complex with an Ac-R-E-R-K-chloromethyl ketone inhibitor.
Summary for 2ID4
| Entry DOI | 10.2210/pdb2id4/pdb |
| Related PRD ID | PRD_000246 |
| Descriptor | Kexin, Ac-RERK-CMK inhibitor, 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total) |
| Functional Keywords | kex2, kexin, furin, proprotein, prohormone, convertase, subtilisin like protease, serine protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Saccharomyces cerevisiae (baker's yeast) More |
| Cellular location | Golgi apparatus, trans-Golgi network membrane; Single-pass type I membrane protein: P13134 |
| Total number of polymer chains | 4 |
| Total formula weight | 113263.51 |
| Authors | Wheatley, J.L.,Holyoak, T. (deposition date: 2006-09-14, release date: 2007-05-01, Last modification date: 2023-11-15) |
| Primary citation | Wheatley, J.L.,Holyoak, T. Differential P1 arginine and lysine recognition in the prototypical proprotein convertase Kex2. Proc.Natl.Acad.Sci.Usa, 104:6626-6631, 2007 Cited by PubMed: 17426142DOI: 10.1073/pnas.0701983104 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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