2IB8
Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase (T2): the importance of potassium and chloride for its structure and function
Summary for 2IB8
Entry DOI | 10.2210/pdb2ib8/pdb |
Related | 2IB7 2IB9 2IBU 2IBW 2IBY |
Descriptor | Acetyl-CoA acetyltransferase, CHLORIDE ION, POTASSIUM ION, ... (6 entities in total) |
Functional Keywords | thiolase fold, potassium ion, chloride, beta-alpha-beta-alpha-beta-alpha-beta-beta topology, alpha-beta-alpha-beta-alpha layered structure, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Mitochondrion: P24752 |
Total number of polymer chains | 4 |
Total formula weight | 167671.81 |
Authors | Haapalainen, A.M.,Wierenga, R.K. (deposition date: 2006-09-11, release date: 2007-04-03, Last modification date: 2023-10-25) |
Primary citation | Haapalainen, A.M.,Merilainen, G.,Pirila, P.L.,Kondo, N.,Fukao, T.,Wierenga, R.K. Crystallographic and Kinetic Studies of Human Mitochondrial Acetoacetyl-CoA Thiolase: The Importance of Potassium and Chloride Ions for Its Structure and Function Biochemistry, 46:4305-4321, 2007 Cited by PubMed: 17371050DOI: 10.1021/bi6026192 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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