2IAY

Crystal structure of a duf1831 family protein (lp2179) from lactobacillus plantarum at 1.20 A resolution

2IAY の概要

• エントリーDOI: 10.2210/pdb2iay/pdb
• 分子名称: Hypothetical protein, CHLORIDE ION, GLYCEROL, ... (4 entities in total)
• 機能のキーワード: structural genomics, joint center for structural genomics, jcsg, protein structure initiative, psi-2, translation
• 由来する生物種: Lactobacillus plantarum
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 12998.55

構造登録者

Joint Center for Structural Genomics (JCSG) (登録日: 2006-09-08, 公開日: 2006-10-10, 最終更新日: 2024-11-06)

主引用文献

Bakolitsa, C.,Kumar, A.,Carlton, D.,Miller, M.D.,Krishna, S.S.,Abdubek, P.,Astakhova, T.,Axelrod, H.L.,Chiu, H.J.,Clayton, T.,Deller, M.C.,Duan, L.,Elsliger, M.A.,Feuerhelm, J.,Grzechnik, S.K.,Grant, J.C.,Han, G.W.,Jaroszewski, L.,Jin, K.K.,Klock, H.E.,Knuth, M.W.,Kozbial, P.,Marciano, D.,McMullan, D.,Morse, A.T.,Nigoghossian, E.,Okach, L.,Oommachen, S.,Paulsen, J.,Reyes, R.,Rife, C.L.,Tien, H.J.,Trout, C.V.,van den Bedem, H.,Weekes, D.,Xu, Q.,Hodgson, K.O.,Wooley, J.,Deacon, A.M.,Godzik, A.,Lesley, S.A.,Wilson, I.A.
Structure of LP2179, the first representative of Pfam family PF08866, suggests a new fold with a role in amino-acid metabolism.
Acta Crystallogr.,Sect.F, 66:1205-1210, 2010

PubMed Abstract: The structure of LP2179, a member of the PF08866 (DUF1831) family, suggests a novel α+β fold comprising two β-sheets packed against a single helix. A remote structural similarity to two other uncharacterized protein families specific to the Bacillus genus (PF08868 and PF08968), as well as to prokaryotic S-adenosylmethionine decarboxylases, is consistent with a role in amino-acid metabolism. Genomic neighborhood analysis of LP2179 supports this functional assignment, which might also then be extended to PF08868 and PF08968.

PubMed: 20944212
DOI: 10.1107/S1744309109023689

実験手法

X-RAY DIFFRACTION (1.2 Å)