2IAO

Crystal structure of squid ganglion DFPase E37Q mutant

Summary for 2IAO

Entry DOI	10.2210/pdb2iao/pdb
Related	1E1A 1PJX 2IAP 2IAQ 2IAR 2IAS 2IAT 2IAU 2IAV 2IAW 2IAX
Descriptor	DIISOPROPYLFLUOROPHOSPHATASE, CALCIUM ION (3 entities in total)
Functional Keywords	phosphotriesterase, beta-propeller, calcium-binding site, hydrolase
Biological source	Loligo vulgaris
Total number of polymer chains	1
Total formula weight	34939.57
Authors	Scharff, E.I.,Koepke, J.,Fritzsch, G.,Luecke, C.,Rueterjans, H. (deposition date: 2006-09-08, release date: 2006-09-26, Last modification date: 2023-08-30)
Primary citation	Scharff, E.I.,Koepke, J.,Fritzsch, G.,Luecke, C.,Rueterjans, H. Crystal structure of diisopropylfluorophosphatase from Loligo vulgaris Structure, 9:493-502, 2001 Cited by PubMed Abstract: Phosphotriesterases (PTE) are enzymes capable of detoxifying organophosphate-based chemical warfare agents by hydrolysis. One subclass of these enzymes comprises the family of diisopropylfluorophosphatases (DFPases). The DFPase reported here was originally isolated from squid head ganglion of Loligo vulgaris and can be characterized as squid-type DFPase. It is capable of hydrolyzing the organophosphates diisopropylfluorophosphate, soman, sarin, tabun, and cyclosarin. PubMed: 11435114 DOI: 10.1016/S0969-2126(01)00610-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation