2IAM

Structural basis for recognition of mutant self by a tumor-specific, MHC class II-restricted TCR

2IAM の概要

• エントリーDOI: 10.2210/pdb2iam/pdb
• 関連するPDBエントリー: 1KLG 1KLU 2IAL 2IAN
• 分子名称: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen, DRB1-1 beta chain, 15-mer peptide from Triosephosphate isomerase, ... (6 entities in total)
• 機能のキーワード: major histocompatibility complex, t cell receptor, t cell stimulation, melanoma, tumor antigen, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P01903 P04229; Membrane; Single-pass membrane protein (Potential): P01848 P01850
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 94206.16

構造登録者

Deng, L.,Langley, R.J.,Mariuzza, R.A. (登録日: 2006-09-08, 公開日: 2007-04-03, 最終更新日: 2023-10-25)

• 主引用文献: Deng, L.,Langley, R.J.,Brown, P.H.,Xu, G.,Teng, L.,Wang, Q.,Gonzales, M.I.,Callender, G.G.,Nishimura, M.I.,Topalian, S.L.,Mariuzza, R.A.; Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor; Nat.Immunol., 8:398-408, 2007; PubMed: 17334368; DOI: 10.1038/ni1447

実験手法

X-RAY DIFFRACTION (2.8 Å)