2IAJ
Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
Summary for 2IAJ
Entry DOI | 10.2210/pdb2iaj/pdb |
Related | 1BQM 1DLO 1SV5 1UWB 2HMI 2IC3 |
Descriptor | Reverse transcriptase/ribonuclease H (p66 RT), Reverse transcriptase/ribonuclease H; p51 RT, MANGANESE (II) ION, ... (7 entities in total) |
Functional Keywords | rt, nnrti, nonnucleoside inhibitor, drug resistance, dna polymerization, hiv, aids, drug design, transferase |
Biological source | Human immunodeficiency virus type 1 BH10 More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 117275.59 |
Authors | Das, K.,Arnold, E. (deposition date: 2006-09-08, release date: 2006-12-19, Last modification date: 2023-08-30) |
Primary citation | Das, K.,Sarafianos, S.G.,Clark, A.D.,Boyer, P.L.,Hughes, S.H.,Arnold, E. Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097. J.Mol.Biol., 365:77-89, 2007 Cited by PubMed: 17056061DOI: 10.1016/j.jmb.2006.08.097 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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