2IAJ

Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Reverse transcriptase/ribonuclease H (p66 RT)	polymer	560	64425.9	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB	Human immunodeficiency virus type 1 BH10
2	B	Reverse transcriptase/ribonuclease H; p51 RT	polymer	447	51970.6	1	UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB	Human immunodeficiency virus type 1 BH10
3	A	MANGANESE (II) ION	non-polymer		54.9	3	Chemie (MN)
4	A	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5	A	ADENOSINE-5'-TRIPHOSPHATE	non-polymer		507.2	1	Chemie (ATP)
6	B	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
7		water	water		18.0	308	Chemie (HOH)

Sequence modifications

A: 1 - 560 (UniProt: P03366)

PDB	External Database	Details
Asn 103	Lys 701	engineered mutation
Cys 181	Tyr 779	engineered mutation
Ser 280	Cys 878	engineered mutation

B: 1 - 447 (UniProt: P03366)

PDB	External Database	Details
Asn 103	Lys 701	engineered mutation
Cys 181	Tyr 779	engineered mutation
Ser 280	Cys 878	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	116396.4
Non-Polymers*	Number of molecules	7
	Total formula weight	879.2
All*	Total formula weight	117275.6

*Water molecules are not included.