2IAJ
Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/ribonuclease H (p66 RT) | polymer | 560 | 64425.9 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) | Human immunodeficiency virus type 1 BH10 | |
| 2 | B (B) | Reverse transcriptase/ribonuclease H; p51 RT | polymer | 447 | 51970.6 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) | Human immunodeficiency virus type 1 BH10 | |
| 3 | C, D, E (A) | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
| 4 | F (A) | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 5 | G (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 6 | H, I (B) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 7 | J, K (A, B) | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 447 (UniProt: P03366)
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 701 | engineered mutation |
| Cys 181 | Tyr 779 | engineered mutation |
| Ser 280 | Cys 878 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 103 | Lys 701 | engineered mutation |
| Cys 181 | Tyr 779 | engineered mutation |
| Ser 280 | Cys 878 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 116396.4 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 879.2 | |
| All* | Total formula weight | 117275.6 |
