2IAJ
Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Reverse transcriptase/ribonuclease H (p66 RT) | polymer | 560 | 64425.9 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) Pfam (PF00075) In PDB | Human immunodeficiency virus type 1 BH10 | |
2 | B | Reverse transcriptase/ribonuclease H; p51 RT | polymer | 447 | 51970.6 | 1 | UniProt (P03366) Pfam (PF00078) Pfam (PF06817) Pfam (PF06815) In PDB | Human immunodeficiency virus type 1 BH10 | |
3 | A | MANGANESE (II) ION | non-polymer | 54.9 | 3 | Chemie (MN) | |||
4 | A | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
5 | A | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
6 | B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
7 | water | water | 18.0 | 308 | Chemie (HOH) |
Sequence modifications
A: 1 - 560 (UniProt: P03366)
B: 1 - 447 (UniProt: P03366)
PDB | External Database | Details |
---|---|---|
Asn 103 | Lys 701 | engineered mutation |
Cys 181 | Tyr 779 | engineered mutation |
Ser 280 | Cys 878 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Asn 103 | Lys 701 | engineered mutation |
Cys 181 | Tyr 779 | engineered mutation |
Ser 280 | Cys 878 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 116396.4 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 879.2 | |
All* | Total formula weight | 117275.6 |