2IAJ

Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with ATP

2IAJ の概要

• エントリーDOI: 10.2210/pdb2iaj/pdb
• 関連するPDBエントリー: 1BQM 1DLO 1SV5 1UWB 2HMI 2IC3
• 分子名称: Reverse transcriptase/ribonuclease H (p66 RT), Reverse transcriptase/ribonuclease H; p51 RT, MANGANESE (II) ION, ... (7 entities in total)
• 機能のキーワード: rt, nnrti, nonnucleoside inhibitor, drug resistance, dna polymerization, hiv, aids, drug design, transferase
• 由来する生物種: Human immunodeficiency virus type 1 BH10; 詳細
• 細胞内の位置: Gag-Pol polyprotein: Host cell membrane; Lipid-anchor. Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P03366 P03366
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 117275.59

構造登録者

Das, K.,Arnold, E. (登録日: 2006-09-08, 公開日: 2006-12-19, 最終更新日: 2023-08-30)

• 主引用文献: Das, K.,Sarafianos, S.G.,Clark, A.D.,Boyer, P.L.,Hughes, S.H.,Arnold, E.; Crystal Structures of Clinically Relevant Lys103Asn/Tyr181Cys Double Mutant HIV-1 Reverse Transcriptase in Complexes with ATP and Non-nucleoside Inhibitor HBY 097.; J.Mol.Biol., 365:77-89, 2007; PubMed: 17056061; DOI: 10.1016/j.jmb.2006.08.097

実験手法

X-RAY DIFFRACTION (2.5 Å)