2IA6
Bypass of Major Benzopyrene-dG Adduct by Y-Family DNA Polymerase with Unique Structural Gap
Summary for 2IA6
Entry DOI | 10.2210/pdb2ia6/pdb |
Related | 2IBK |
Descriptor | DNA polymerase IV, 5'-D(*GP*GP*GP*GP*GP*AP*AP*GP*GP*AP*TP*TP*A)-3', 5'-D(*TP*CP*AP*TP*GP*AP*AP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3', ... (10 entities in total) |
Functional Keywords | benzo pyrene, carcinogen, lesion bypass, polymerase, translesion synthesis, dpo4, transferase-dna complex, transferase/dna |
Biological source | Sulfolobus solfataricus |
Cellular location | Cytoplasm (Probable): Q97W02 |
Total number of polymer chains | 6 |
Total formula weight | 101411.65 |
Authors | Bauer, J.,Ling, H.,Sayer, J.M.,Xing, G.,Yagi, H.,Jerina, D.M. (deposition date: 2006-09-07, release date: 2007-09-11, Last modification date: 2023-08-30) |
Primary citation | Bauer, J.,Xing, G.,Yagi, H.,Sayer, J.M.,Jerina, D.M.,Ling, H. A structural gap in Dpo4 supports mutagenic bypass of a major benzo[a]pyrene dG adduct in DNA through template misalignment. Proc.Natl.Acad.Sci.Usa, 104:14905-14910, 2007 Cited by PubMed: 17848527DOI: 10.1073/pnas.0700717104 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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