2I5Y

Crystal structure of CD4M47, a scorpion-toxin mimic of CD4, in complex with HIV-1 YU2 GP120 envelope glycoprotein and anti-HIV-1 antibody 17B

Summary for 2I5Y

• Entry DOI: 10.2210/pdb2i5y/pdb
• Related: 1YYL 1YYM 2I60
• Descriptor: Exterior membrane glycoprotein(GP120), Antibody 17B Light chain, Antibody 17B Heavy chain, ... (6 entities in total)
• Functional Keywords: hiv-1, gp120, yu2, scorpion toxin, cd4 mimic, cd4m47, antibody, viral protein-immune system complex, viral protein/immune system
• Biological source: Human immunodeficiency virus; More
• Total number of polymer chains: 8
• Total formula weight: 174974.76

Authors

Huang, C.-C.,Kwong, P.D. (deposition date: 2006-08-26, release date: 2006-10-10, Last modification date: 2023-08-30)

• Primary citation: Stricher, F.,Huang, C.C.,Descours, A.,Duquesnoy, S.,Combes, O.,Decker, J.M.,Kwon, Y.D.,Lusso, P.,Shaw, G.M.,Vita, C.,Kwong, P.D.,Martin, L.; Combinatorial optimization of a CD4-mimetic miniprotein and cocrystal structures with HIV-1 gp120 envelope glycoprotein.; J.Mol.Biol., 382:510-524, 2008; PubMed: 18619974; DOI: 10.1016/j.jmb.2008.06.069

Experimental method

X-RAY DIFFRACTION (2.2 Å)