2I40

Cdk2/Cyclin A complexed with a thiophene carboxamide inhibitor

Summary for 2I40

• Entry DOI: 10.2210/pdb2i40/pdb
• Related: 1FIN
• Descriptor: Cell division protein kinase 2, Cyclin-A2, 5-[5,6-BIS(METHYLOXY)-1H-BENZIMIDAZOL-1-YL]-3-{[1-(2-CHLOROPHENYL)ETHYL]OXY}-2-THIOPHENECARBOXAMIDE, ... (4 entities in total)
• Functional Keywords: cdk2, cyclin, kinase, transferase-cell cycle complex, transferase/cell cycle
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: P20248
• Total number of polymer chains: 4
• Total formula weight: 128603.86

Authors

Shewchuk, L.M. (deposition date: 2006-08-21, release date: 2006-10-10, Last modification date: 2023-08-30)

• Primary citation: Bamborough, P.,Christopher, J.A.,Cutler, G.J.,Dickson, M.C.,Mellor, G.W.,Morey, J.V.,Patel, C.B.,Shewchuk, L.M.; 5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-epsilon kinase; Bioorg.Med.Chem.Lett., 16:6236-6240, 2006; PubMed: 16997559; DOI: 10.1016/j.bmcl.2006.09.018

Experimental method

X-RAY DIFFRACTION (2.8 Å)