2I3I

Structure of an ML-IAP/XIAP chimera bound to a peptidomimetic

2I3I の概要

• エントリーDOI: 10.2210/pdb2i3i/pdb
• 関連するPDBエントリー: 1OXN 1OXQ 1OY7 1TW6
• 分子名称: Baculoviral IAP repeat-containing protein 7, ZINC ION, (3R,6R,9AR)-2,2-DIMETHYL-6-[(N-METHYL-L-ALANYL)AMINO]-N-(3-METHYL-1-PHENYL-1H-PYRAZOL-5-YL)-5-OXO-2,3,5,6,9,9A-HEXAHYDRO[1,3]THIAZOLO[3,2-A]AZEPINE-3-CARBOXAMIDE, ... (7 entities in total)
• 機能のキーワード: zinc binding, peptide complex, apoptosis inhibition, peptidomimetic, small molecule, drug design, inhibitor-apoptosis complex, inhibitor/apoptosis
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q96CA5
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31419.52

構造登録者

Fairbrother, W.J.,Franklin, M.C. (登録日: 2006-08-18, 公開日: 2006-09-19, 最終更新日: 2024-04-03)

• 主引用文献: Zobel, K.,Wang, L.,Varfolomeev, E.,Franklin, M.C.,Elliott, L.O.,Wallweber, H.J.,Okawa, D.C.,Flygare, J.A.,Vucic, D.,Fairbrother, W.J.,Deshayes, K.; Design, synthesis, and biological activity of a potent Smac mimetic that sensitizes cancer cells to apoptosis by antagonizing IAPs.; Acs Chem.Biol., 1:525-533, 2006; PubMed: 17168540; DOI: 10.1021/cb600276q

実験手法

X-RAY DIFFRACTION (2.3 Å)