2I0Y

cFMS tyrosine kinase (FGF KID) in complex with an arylamide inhibitor

2I0Y の概要

• エントリーDOI: 10.2210/pdb2i0y/pdb
• 関連するPDBエントリー: 2I0V
• 分子名称: cFMS Tyrosine Kinase, 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE (3 entities in total)
• 機能のキーワード: tyrosine kinase, kinase inhibitor complex, transferase
• 由来する生物種: Homo sapiens (human); 詳細
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein: P07333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 38403.86

構造登録者

Schubert, C.,Schalk-Hihi, C. (登録日: 2006-08-11, 公開日: 2006-11-28, 最終更新日: 2024-02-21)

• 主引用文献: Schubert, C.,Schalk-Hihi, C.,Struble, G.T.,Ma, H.C.,Petrounia, I.P.,Brandt, B.,Deckman, I.C.,Patch, R.J.,Player, M.R.,Spurlino, J.C.,Springer, B.A.; Crystal structure of the tyrosine kinase domain of colony-stimulating factor-1 receptor (cFMS) in complex with two inhibitors.; J.Biol.Chem., 282:4094-4101, 2007; PubMed: 17132624; DOI: 10.1074/jbc.M608183200

実験手法

X-RAY DIFFRACTION (1.9 Å)