2I0J

Benzopyrans are Selective Estrogen Receptor beta Agonists (SERBAs) with Novel Activity in Models of Benign Prostatic Hyperplasia

2I0J の概要

• エントリーDOI: 10.2210/pdb2i0j/pdb
• 関連するPDBエントリー: 2I0G
• 分子名称: Estrogen receptor alpha, (3AS,4R,9BR)-4-(4-HYDROXYPHENYL)-1,2,3,3A,4,9B-HEXAHYDROCYCLOPENTA[C]CHROMEN-8-OL (2 entities in total)
• 機能のキーワード: nuclear receptor ligand binding domain, transcription
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 112399.71

構造登録者

Wang, Y. (登録日: 2006-08-10, 公開日: 2006-10-24, 最終更新日: 2023-08-30)

主引用文献

Norman, B.H.,Dodge, J.A.,Richardson, T.I.,Borromeo, P.S.,Lugar, C.W.,Jones, S.A.,Chen, K.,Wang, Y.,Durst, G.L.,Barr, R.J.,Montrose-Rafizadeh, C.,Osborne, H.E.,Amos, R.M.,Guo, S.,Boodhoo, A.,Krishnan, V.
Benzopyrans are selective estrogen receptor Beta agonists with novel activity in models of benign prostatic hyperplasia.
J.Med.Chem., 49:6155-6157, 2006

PubMed Abstract: Benzopyran selective estrogen receptor beta agonist-1 (SERBA-1) shows potent, selective binding and agonist function in estrogen receptor beta (ERbeta) in vitro assays. X-ray crystal structures of SERBA-1 in ERalpha and beta help explain observed beta-selectivity of this ligand. SERBA-1 in vivo demonstrates involution of the ventral prostate in CD-1 mice (ERbeta effect), while having no effect on gonadal hormone levels (ERalpha effect) at 10x the efficacious dose, consistent with in vitro properties of this molecule.

PubMed: 17034120
DOI: 10.1021/jm060491j

実験手法

X-RAY DIFFRACTION (2.9 Å)