2I0D

Crystal structure of AD-81 complexed with wild type HIV-1 protease

Summary for 2I0D

Entry DOI	10.2210/pdb2i0d/pdb
Related	2IOA
Descriptor	Protease, PHOSPHATE ION, (5S)-3-(3-ACETYLPHENYL)-N-[(1S,2R)-1-BENZYL-2-HYDROXY-3-{ISOBUTYL[(4-METHOXYPHENYL)SULFONYL]AMINO}PROPYL]-2-OXO-1,3-OXAZOLIDINE-5-CARBOXAMIDE, ... (5 entities in total)
Functional Keywords	drug design, hiv-1 protease, protease inhibitors, hydrolase
Biological source	Human immunodeficiency virus 1
Total number of polymer chains	2
Total formula weight	22708.25
Authors	Nalam, M.N.L.,Schiffer, C.A.,Ali, A.,Reddy, K.K.,Cao, H.,Anjum, S.G.,Rana, T.M. (deposition date: 2006-08-10, release date: 2006-12-19, Last modification date: 2023-08-30)
Primary citation	Ali, A.,Reddy, G.S.,Cao, H.,Anjum, S.G.,Nalam, M.N.,Schiffer, C.A.,Rana, T.M. Discovery of HIV-1 Protease Inhibitors with Picomolar Affinities Incorporating N-Aryl-oxazolidinone-5-carboxamides as Novel P2 Ligands. J.Med.Chem., 49:7342-7356, 2006 Cited by PubMed: 17149864 DOI: 10.1021/jm060666p PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation