2HXQ
crystal structure of Chek1 in complex with inhibitor 2
Summary for 2HXQ
Entry DOI | 10.2210/pdb2hxq/pdb |
Related | 2HXL |
Descriptor | Serine/threonine-protein kinase Chk1, 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE (3 entities in total) |
Functional Keywords | chek1, kinase, cell cycle checkpoint, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: O14757 |
Total number of polymer chains | 1 |
Total formula weight | 37177.45 |
Authors | |
Primary citation | Huang, S.,Garbaccio, R.M.,Fraley, M.E.,Steen, J.,Kreatsoulas, C.,Hartman, G.,Stirdivant, S.,Drakas, B.,Rickert, K.,Walsh, E.,Hamilton, K.,Buser, C.A.,Hardwick, J.,Mao, X.,Abrams, M.,Beck, S.,Tao, W.,Lobell, R.,Sepp-Lorenzino, L.,Yan, Y.,Ikuta, M.,Murphy, J.Z.,Sardana, V.,Munshi, S.,Kuo, L.,Reilly, M.,Mahan, E. Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors. Bioorg.Med.Chem.Lett., 16:5907-5912, 2006 Cited by PubMed: 16990002DOI: 10.1016/j.bmcl.2006.08.053 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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