2HXQ
crystal structure of Chek1 in complex with inhibitor 2
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serine/threonine-protein kinase Chk1 | polymer | 322 | 36791.0 | 1 | UniProt (O14757) Pfam (PF00069) In PDB | Homo sapiens (human) | |
2 | A | 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE | non-polymer | 386.5 | 1 | Chemie (373) | |||
3 | water | water | 18.0 | 114 | Chemie (HOH) |
Sequence modifications
A: 2 - 307 (UniProt: O14757)
PDB | External Database | Details |
---|---|---|
Arg 308 | - | cloning artifact |
Thr 309 | - | cloning artifact |
Pro 310 | - | cloning artifact |
Gly 311 | - | cloning artifact |
Ser 312 | - | cloning artifact |
Gly 313 | - | cloning artifact |
Trp 314 | - | cloning artifact |
Ser 315 | - | cloning artifact |
Lys 316 | - | cloning artifact |
Glu 317 | - | cloning artifact |
His 318 | - | expression tag |
His 319 | - | expression tag |
His 320 | - | expression tag |
His 321 | - | expression tag |
His 322 | - | expression tag |
His 323 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36791.0 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 386.5 | |
All* | Total formula weight | 37177.4 |