2HX2
Bovine eNOS heme domain complexed with (4S)-N-{4-Amino-5-[(2-aminoethyl)-hydroxyamino]-pentyl}-N'-nitroguanidine
Summary for 2HX2
Entry DOI | 10.2210/pdb2hx2/pdb |
Related | 2HX3 2HX4 |
Descriptor | Nitric-oxide synthase, CACODYLATE ION, ACETATE ION, ... (9 entities in total) |
Functional Keywords | nitric oxide synthase, heme enzyme, inhibitor, oxidoreductase |
Biological source | Bos taurus (cattle) |
Cellular location | Cell membrane: P29473 |
Total number of polymer chains | 2 |
Total formula weight | 96709.87 |
Authors | Igarashi, J.,Li, H.,Poulos, T.L. (deposition date: 2006-08-02, release date: 2007-04-24, Last modification date: 2024-02-14) |
Primary citation | Seo, J.,Igarashi, J.,Li, H.,Martasek, P.,Roman, L.J.,Poulos, T.L.,Silverman, R.B. Structure-Based Design and Synthesis of N(omega)-Nitro-l-Arginine-Containing Peptidomimetics as Selective Inhibitors of Neuronal Nitric Oxide Synthase. Displacement of the Heme Structural Water. J.Med.Chem., 50:2089-2099, 2007 Cited by PubMed: 17425297DOI: 10.1021/jm061305c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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