2HWP
Crystal structure of Src kinase domain in complex with covalent inhibitor PD168393
Summary for 2HWP
Entry DOI | 10.2210/pdb2hwp/pdb |
Related | 2HWO |
Descriptor | Proto-oncogene tyrosine-protein kinase Src, N-[4-(3-BROMO-PHENYLAMINO)-QUINAZOLIN-6-YL]-ACRYLAMIDE (3 entities in total) |
Functional Keywords | kinase, covalent, quinazoline, modification, transferase |
Biological source | Gallus gallus (chicken) |
Cellular location | Cell membrane : P00523 |
Total number of polymer chains | 2 |
Total formula weight | 66223.85 |
Authors | Rauh, D.,Blair, J.A.,Shokat, K.M. (deposition date: 2006-08-01, release date: 2007-02-27, Last modification date: 2021-10-20) |
Primary citation | Blair, J.A.,Rauh, D.,Kung, C.,Yun, C.H.,Fan, Q.W.,Rode, H.,Zhang, C.,Eck, M.J.,Weiss, W.A.,Shokat, K.M. Structure-guided development of affinity probes for tyrosine kinases using chemical genetics. Nat.Chem.Biol., 3:229-238, 2007 Cited by PubMed: 17334377DOI: 10.1038/nchembio866 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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