2HV9

Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase in complex with sinefungin

Summary for 2HV9

Entry DOI	10.2210/pdb2hv9/pdb
Related	1ri1 1ri2 1ri3 1ri4 1ri5 1z3c
Descriptor	mRNA cap guanine-N7 methyltransferase, SINEFUNGIN (3 entities in total)
Functional Keywords	mrna, cap, methyltransferase, inhibitor, transferase
Biological source	Encephalitozoon cuniculi
Cellular location	Nucleus (By similarity): Q8SR66
Total number of polymer chains	1
Total formula weight	35205.07
Authors	Lima, C.D. (deposition date: 2006-07-27, release date: 2006-09-19, Last modification date: 2023-08-30)
Primary citation	Zheng, S.,Hausmann, S.,Liu, Q.,Ghosh, A.,Schwer, B.,Lima, C.D.,Shuman, S. Mutational Analysis of Encephalitozoon cuniculi mRNA Cap (Guanine-N7) Methyltransferase, Structure of the Enzyme Bound to Sinefungin, and Evidence That Cap Methyltransferase Is the Target of Sinefungin's Antifungal Activity J.Biol.Chem., 281:35904-35913, 2006 Cited by PubMed: 16971388 DOI: 10.1074/jbc.M607292200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation