2HRL

Siglec-7 in complex with GT1b

Summary for 2HRL

Entry DOI	10.2210/pdb2hrl/pdb
Related	1O7S 1O7V 2DF3 2G5R
Descriptor	Sialic acid-binding Ig-like lectin 7, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-3)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total)
Functional Keywords	ig-like domain, siglec, ganglioside, siglec-7, cell adhesion
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: Q9Y286
Total number of polymer chains	1
Total formula weight	16106.75
Authors	Attrill, H.,Imamura, A.,Sharma, R.S.,Kiso, M.,Crocker, P.R.,van Aalten, D.M.F. (deposition date: 2006-07-20, release date: 2006-08-15, Last modification date: 2023-10-25)
Primary citation	Attrill, H.,Imamura, A.,Sharma, R.S.,Kiso, M.,Crocker, P.R.,van Aalten, D.M.F. Siglec-7 Undergoes a Major Conformational Change When Complexed with the {alpha}(2,8)-Disialylganglioside GT1b J.Biol.Chem., 281:32774-32783, 2006 Cited by PubMed: 16895906 DOI: 10.1074/jbc.M601714200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation