2HRL
Siglec-7 in complex with GT1b
Summary for 2HRL
Entry DOI | 10.2210/pdb2hrl/pdb |
Related | 1O7S 1O7V 2DF3 2G5R |
Descriptor | Sialic acid-binding Ig-like lectin 7, N-acetyl-alpha-neuraminic acid-(2-8)-N-acetyl-alpha-neuraminic acid-(2-3)-[2-acetamido-2-deoxy-beta-D-galactopyranose-(1-4)]beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (5 entities in total) |
Functional Keywords | ig-like domain, siglec, ganglioside, siglec-7, cell adhesion |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: Q9Y286 |
Total number of polymer chains | 1 |
Total formula weight | 16106.75 |
Authors | Attrill, H.,Imamura, A.,Sharma, R.S.,Kiso, M.,Crocker, P.R.,van Aalten, D.M.F. (deposition date: 2006-07-20, release date: 2006-08-15, Last modification date: 2023-10-25) |
Primary citation | Attrill, H.,Imamura, A.,Sharma, R.S.,Kiso, M.,Crocker, P.R.,van Aalten, D.M.F. Siglec-7 Undergoes a Major Conformational Change When Complexed with the {alpha}(2,8)-Disialylganglioside GT1b J.Biol.Chem., 281:32774-32783, 2006 Cited by PubMed: 16895906DOI: 10.1074/jbc.M601714200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.85 Å) |
Structure validation
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