Crystal structure of LSD1

Summary for 2HKO

DescriptorLysine-specific histone demethylase 1, FLAVIN-ADENINE DINUCLEOTIDE (3 entities in total)
Functional Keywordsswirm domain, fad binding domain, coiled-coil, amine oxidase domain, oxidoreductase
Biological sourceHomo sapiens (human)
Cellular locationNucleus O60341
Total number of polymer chains1
Total molecular weight74673
Chen, Y.,Yang, Y.T.,Wang, F.,Yanane, K.,Zhang, Y.,Lei, M. (deposition date: 2006-07-05, release date: 2006-08-29, Last modification date: 2011-07-13)
Primary citation
Chen, Y.,Yang, Y.,Wang, F.,Wan, K.,Yamane, K.,Zhang, Y.,Lei, M.
Crystal structure of human histone lysine-specific demethylase 1 (LSD1).
Proc.Natl.Acad.Sci.Usa, 103:13956-13961, 2006
PubMed: 16956976 (PDB entries with the same primary citation)
DOI: 10.1073/pnas.0606381103
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.275312.5%8.7%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution