2HK9

Crystal structure of shikimate dehydrogenase from aquifex aeolicus in complex with shikimate and NADP+ at 2.2 angstrom resolution

2HK9 の概要

• エントリーDOI: 10.2210/pdb2hk9/pdb
• 関連するPDBエントリー: 1WXD 2EV9 2HK7 2HK8
• 分子名称: Shikimate dehydrogenase, 2'-MONOPHOSPHOADENOSINE-5'-DIPHOSPHATE, (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID, ... (5 entities in total)
• 機能のキーワード: shikimate pathway, shikimate dehydrogenase, drug design, oxidoreductase
• 由来する生物種: Aquifex aeolicus
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 127202.11

構造登録者

Gan, J.H.,Prabakaran, P.,Gu, Y.J.,Andrykovitch, M.,Li, Y.,Liu, H.H.,Yan, H.,Ji, X. (登録日: 2006-07-03, 公開日: 2007-06-19, 最終更新日: 2023-08-30)

• 主引用文献: Gan, J.,Wu, Y.,Prabakaran, P.,Gu, Y.,Li, Y.,Andrykovitch, M.,Liu, H.,Gong, Y.,Yan, H.,Ji, X.; Structural and biochemical analyses of shikimate dehydrogenase AroE from Aquifex aeolicus: implications for the catalytic mechanism.; Biochemistry, 46:9513-9522, 2007; PubMed: 17649975; DOI: 10.1021/bi602601e

実験手法

X-RAY DIFFRACTION (2.2 Å)