2HK5

Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247

Summary for 2HK5

Entry DOI	10.2210/pdb2hk5/pdb
Descriptor	Tyrosine-protein kinase HCK, 3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL (3 entities in total)
Functional Keywords	hck, src-family, kinase domain, transferase
Biological source	Homo sapiens (human)
Cellular location	Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631
Total number of polymer chains	1
Total formula weight	31402.36
Authors	Walter, R.L.,Mekel, M.J.,Evdokimov, A.G.,Pokross, M.E.,Sabat, M.P. (deposition date: 2006-07-03, release date: 2006-09-05, Last modification date: 2024-04-03)
Primary citation	Sabat, M.,VanRens, J.C.,Laufersweiler, M.J.,Brugel, T.A.,Maier, J.,Golebiowski, A.,De, B.,Easwaran, V.,Hsieh, L.C.,Walter, R.L.,Mekel, M.J.,Evdokimov, A.,Janusz, M.J. The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck). Bioorg.Med.Chem.Lett., 16:5973-5977, 2006 Cited by PubMed: 16997556 DOI: 10.1016/j.bmcl.2006.08.132 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation