2HK5

Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247

2HK5 の概要

• エントリーDOI: 10.2210/pdb2hk5/pdb
• 分子名称: Tyrosine-protein kinase HCK, 3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL (3 entities in total)
• 機能のキーワード: hck, src-family, kinase domain, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Isoform 1: Lysosome. Isoform 2: Cell membrane ; Lipid-anchor . Cytoplasmic vesicle, secretory vesicle: P08631
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 31402.36

構造登録者

Walter, R.L.,Mekel, M.J.,Evdokimov, A.G.,Pokross, M.E.,Sabat, M.P. (登録日: 2006-07-03, 公開日: 2006-09-05, 最終更新日: 2024-04-03)

• 主引用文献: Sabat, M.,VanRens, J.C.,Laufersweiler, M.J.,Brugel, T.A.,Maier, J.,Golebiowski, A.,De, B.,Easwaran, V.,Hsieh, L.C.,Walter, R.L.,Mekel, M.J.,Evdokimov, A.,Janusz, M.J.; The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).; Bioorg.Med.Chem.Lett., 16:5973-5977, 2006; PubMed: 16997556; DOI: 10.1016/j.bmcl.2006.08.132

実験手法

X-RAY DIFFRACTION (2 Å)