2HJH

Crystal Structure of the Sir2 deacetylase

2HJH の概要

• エントリーDOI: 10.2210/pdb2hjh/pdb
• 分子名称: NAD-dependent histone deacetylase SIR2, ZINC ION, (2R,3R,4S,5R)-5-({[(R)-{[(R)-{[(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]OXY}METHYL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL ACETATE, ... (5 entities in total)
• 機能のキーワード: protein, sirtuin, acetyl-adp-ribose, nicotinamide, hydrolase
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• 細胞内の位置: Nucleus, nucleolus : P06700
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 82977.76

構造登録者

Hall, B.E.,Ellenberger, T.E. (登録日: 2006-06-30, 公開日: 2008-04-08, 最終更新日: 2017-10-18)

• 主引用文献: Hall, B.E.,Buchberger, J.R.,Gerber, S.A.,Ambrosio, A.L.B.,Gygi, S.P.,Filman, D.,Moazed, D.,Ellenberger, T.; Autoregulation of the yeast Sir2 deacetylase by reaction and trapping of a pseudosubstrate motif in the active site; To be Published,

実験手法

X-RAY DIFFRACTION (1.85 Å)