2HHH
Crystal structure of kasugamycin bound to the 30S ribosomal subunit
Summary for 2HHH
Entry DOI | 10.2210/pdb2hhh/pdb |
Descriptor | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... (22 entities in total) |
Functional Keywords | ribosome, 30s, antibiotics, initiation |
Biological source | Thermus thermophilus More |
Total number of polymer chains | 21 |
Total formula weight | 784440.75 |
Authors | Schluenzen, F. (deposition date: 2006-06-28, release date: 2006-09-26, Last modification date: 2024-04-03) |
Primary citation | Schluenzen, F.,Takemoto, C.,Wilson, D.N.,Kaminishi, T.,Harms, J.M.,Hanawa-Suetsugu, K.,Szaflarski, W.,Kawazoe, M.,Shirouzo, M.,Nierhaus, K.H.,Yokoyama, S.,Fucini, P. The antibiotic kasugamycin mimics mRNA nucleotides to destabilize tRNA binding and inhibit canonical translation initiation. Nat.Struct.Mol.Biol., 13:871-878, 2006 Cited by PubMed: 16998488DOI: 10.1038/nsmb1145 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.35 Å) |
Structure validation
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