2HH5

Crystal Structure of Cathepsin S in complex with a Zinc mediated non-covalent arylaminoethyl amide

Summary for 2HH5

• Entry DOI: 10.2210/pdb2hh5/pdb
• Related: 2F1G 2HHN
• Descriptor: Cathepsin S, ZINC ION, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: cathepsin s, noncovalent, inhibition, zinc, arylaminoethyl-amides, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P25774
• Total number of polymer chains: 2
• Total formula weight: 50391.34

Authors

Spraggon, G.,Hornsby, M.,Lesley, S.A.,Tully, D.C.,Harris, J.L.,Karenewsky, D.S. (deposition date: 2006-06-27, release date: 2006-08-15, Last modification date: 2023-08-30)

• Primary citation: Tully, D.C.,Liu, H.,Chatterjee, A.K.,Alper, P.B.,Epple, R.,Williams, J.A.,Roberts, M.J.,Woodmansee, D.H.,Masick, B.T.,Tumanut, C.,Li, J.,Spraggon, G.,Hornsby, M.,Chang, J.,Tuntland, T.,Hollenbeck, T.,Gordon, P.,Harris, J.L.,Karanewsky, D.S.; Synthesis and SAR of arylaminoethyl amides as noncovalent inhibitors of cathepsin S: P3 cyclic ethers.; Bioorg.Med.Chem.Lett., 16:5112-5117, 2006; PubMed: 16876402; DOI: 10.1016/j.bmcl.2006.07.033

Experimental method

X-RAY DIFFRACTION (1.8 Å)