2HFZ

Crystal structure of RNA dependent RNA polymerase domain from West Nile virus

2HFZ の概要

• エントリーDOI: 10.2210/pdb2hfz/pdb
• 関連するPDBエントリー: 2HCN 2HCS
• 分子名称: RNA-directed RNA polymerase(NS5), MAGNESIUM ION, ZINC ION, ... (4 entities in total)
• 機能のキーワード: west nile virus rna polymerase, structural genomics, marseilles structural genomics program @ afmb, msgp, vizier, viral enzymes involved in replication, transferase
• 由来する生物種: Kunjin virus
• 細胞内の位置: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): P14335
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 73848.28

構造登録者

Egloff, M.P.,Malet, H.,Marseilles Structural Genomics Program @ AFMB (MSGP) (登録日: 2006-06-26, 公開日: 2007-02-06, 最終更新日: 2023-08-30)

• 主引用文献: Malet, H.,Egloff, M.P.,Selisko, B.,Butcher, R.E.,Wright, P.J.,Roberts, M.,Gruez, A.,Sulzenbacher, G.,Vonrhein, C.,Bricogne, G.,Mackenzie, J.M.,Khromykh, A.A.,Davidson, A.D.,Canard, B.; Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5; J.Biol.Chem., 282:10678-10689, 2007; PubMed: 17287213; DOI: 10.1074/jbc.M607273200

実験手法

X-RAY DIFFRACTION (3 Å)