2HFU

Crystal structure of L. major mevalonate kinase in complex with R-mevalonate

Summary for 2HFU

Entry DOI	10.2210/pdb2hfu/pdb
Related	2hfs
Descriptor	Mevalonate kinase, putative, (R)-MEVALONATE (3 entities in total)
Functional Keywords	ghmp kinase, mevalonate kinase, trypanosomatid parasite, transferase
Biological source	Leishmania major
Total number of polymer chains	2
Total formula weight	71770.67
Authors	Sgraja, T.,Hunter, W.N. (deposition date: 2006-06-26, release date: 2007-04-17, Last modification date: 2024-04-03)
Primary citation	Sgraja, T.,Smith, T.K.,Hunter, W.N. Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase. Bmc Struct.Biol., 7:20-20, 2007 Cited by PubMed Abstract: Isoprenoid precursor synthesis via the mevalonate route in humans and pathogenic trypanosomatids is an important metabolic pathway. There is however, only limited information available on the structure and reactivity of the component enzymes in trypanosomatids. Since isoprenoid biosynthesis is essential for trypanosomatid viability and may provide new targets for therapeutic intervention it is important to characterize the pathway components. PubMed: 17397541 DOI: 10.1186/1472-6807-7-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation