2HFU

Crystal structure of L. major mevalonate kinase in complex with R-mevalonate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004496	molecular_function	mevalonate kinase activity
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006629	biological_process	lipid metabolic process
A	0006694	biological_process	steroid biosynthetic process
A	0008202	biological_process	steroid metabolic process
A	0008299	biological_process	isoprenoid biosynthetic process
A	0016126	biological_process	sterol biosynthetic process
A	0016301	molecular_function	kinase activity
A	0016740	molecular_function	transferase activity
A	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
A	0020015	cellular_component	glycosome
B	0000166	molecular_function	nucleotide binding
B	0004496	molecular_function	mevalonate kinase activity
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0006629	biological_process	lipid metabolic process
B	0006694	biological_process	steroid biosynthetic process
B	0008202	biological_process	steroid metabolic process
B	0008299	biological_process	isoprenoid biosynthetic process
B	0016126	biological_process	sterol biosynthetic process
B	0016301	molecular_function	kinase activity
B	0016740	molecular_function	transferase activity
B	0019287	biological_process	isopentenyl diphosphate biosynthetic process, mevalonate pathway
B	0020015	cellular_component	glycosome

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE MEV A 400

Chain	Residue
A	GLU24
A	HOH1138
A	HIS25
A	VAL27
A	SER152
A	TYR167
A	ARG169
A	THR283
A	HOH883
A	HOH903

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	THR198

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	THR198

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site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
A	ALA196

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site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1fwk

Chain	Residue	Details
B	ALA196

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