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2HFU

Crystal structure of L. major mevalonate kinase in complex with R-mevalonate

Functional Information from GO Data
ChainGOidnamespacecontents
A0004496molecular_functionmevalonate kinase activity
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0008299biological_processisoprenoid biosynthetic process
A0019287biological_processisopentenyl diphosphate biosynthetic process, mevalonate pathway
A0020015cellular_componentglycosome
B0004496molecular_functionmevalonate kinase activity
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0008299biological_processisoprenoid biosynthetic process
B0019287biological_processisopentenyl diphosphate biosynthetic process, mevalonate pathway
B0020015cellular_componentglycosome
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE MEV A 400
ChainResidue
AGLU24
AHOH1138
AHIS25
AVAL27
ASER152
ATYR167
AARG169
ATHR283
AHOH883
AHOH903

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1fwk
ChainResidueDetails
ATHR198

site_idCSA2
Number of Residues1
DetailsAnnotated By Reference To The Literature 1fwk
ChainResidueDetails
BTHR198

site_idCSA3
Number of Residues1
DetailsAnnotated By Reference To The Literature 1fwk
ChainResidueDetails
AALA196

site_idCSA4
Number of Residues1
DetailsAnnotated By Reference To The Literature 1fwk
ChainResidueDetails
BALA196

253795

PDB entries from 2026-05-20

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