2HE8

Crystal structure of 17alpha-hydroxysteroid dehydrogenase in its apo-form

Summary for 2HE8

• Entry DOI: 10.2210/pdb2he8/pdb
• Related: 2HDJ 2HE5 2HEJ
• Descriptor: Aldo-keto reductase family 1, member C21, ACETATE ION, BETA-MERCAPTOETHANOL, ... (5 entities in total)
• Functional Keywords: 17a-hsd, akr1c21, akr, aldo-keto reductase, hsd, hydroxysteroid dehydrogenase, apo-form, oxidoreductase
• Biological source: Mus musculus (house mouse)
• Total number of polymer chains: 2
• Total formula weight: 74596.01

Authors

Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-the, V.,Labrie, F.,Breton, R. (deposition date: 2006-06-21, release date: 2006-12-05, Last modification date: 2023-12-06)

• Primary citation: Faucher, F.,Pereira de Jesus-Tran, K.,Cantin, L.,Luu-The, V.,Labrie, F.,Breton, R.; Crystal Structures of Mouse 17alpha-Hydroxysteroid Dehydrogenase (Apoenzyme and Enzyme-NADP(H) Binary Complex): Identification of Molecular Determinants Responsible for the Unique 17alpha-reductive Activity of this Enzyme.; J.Mol.Biol., 364:747-763, 2006; PubMed: 17034817; DOI: 10.1016/j.jmb.2006.09.030

Experimental method

X-RAY DIFFRACTION (1.9 Å)