Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide

Summary for 2HBH

Related1DB1 2HC4 2HCD
DescriptorVitamin D receptor, SRC-1 from Nuclear receptor coactivator 1, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z), ... (4 entities in total)
Functional Keywordsalpha helical sandwich, gene regulation
Biological sourceDanio rerio (zebrafish)
Cellular locationNucleus Q9PTN2
Nucleus (By similarity) Q15788
Total number of polymer chains2
Total molecular weight36231.29
Rochel, N.,Hourai, S.,Moras, D. (deposition date: 2006-06-14, release date: 2007-05-01, Last modification date: 2011-07-13)
Primary citation
Rochel, N.,Hourai, S.,Perez-Garcia, X.,Rumbo, A.,Mourino, A.,Moras, D.
Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol
Arch.Biochem.Biophys., 460:172-176, 2007
PubMed: 17346665 (PDB entries with the same primary citation)
DOI: 10.1016/j.abb.2007.01.031
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.254130.4%5.3%1.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution