2HBH
Crystal structure of Vitamin D nuclear receptor ligand binding domain bound to a locked side-chain analog of calcitriol and SRC-1 peptide
Summary for 2HBH
Entry DOI | 10.2210/pdb2hbh/pdb |
Related | 1DB1 2HC4 2HCD |
Descriptor | Vitamin D receptor, SRC-1 from Nuclear receptor coactivator 1, 1,3-CYCLOHEXANEDIOL, 4-METHYLENE-5-[(2E)-[(1S,3AS,7AS)-OCTAHYDRO-1-(5-HYDROXY-5-METHYL-1,3-HEXADIYNYL)-7A-METHYL-4H-INDEN-4-YLIDENE]ETHYLIDENE]-, (1R,3S,5Z), ... (4 entities in total) |
Functional Keywords | alpha helical sandwich, gene regulation |
Biological source | Danio rerio (zebrafish) More |
Cellular location | Nucleus: Q9PTN2 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 2 |
Total formula weight | 36231.29 |
Authors | Rochel, N.,Hourai, S.,Moras, D. (deposition date: 2006-06-14, release date: 2007-05-01, Last modification date: 2023-10-25) |
Primary citation | Rochel, N.,Hourai, S.,Perez-Garcia, X.,Rumbo, A.,Mourino, A.,Moras, D. Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol Arch.Biochem.Biophys., 460:172-176, 2007 Cited by PubMed: 17346665DOI: 10.1016/j.abb.2007.01.031 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.65 Å) |
Structure validation
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