2HAI

Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.

2HAI の概要

• エントリーDOI: 10.2210/pdb2hai/pdb
• 関連するPDBエントリー: 1OS5
• 分子名称: HEPATITIS C VIRUS NS5B RNA POLYMERASE, (6S)-6-CYCLOPENTYL-6-[2-(3-FLUORO-4-ISOPROPOXYPHENYL)ETHYL]-4-HYDROXY-5,6-DIHYDRO-2H-PYRAN-2-ONE (3 entities in total)
• 機能のキーワード: hcv rna polymerase, transferase
• 由来する生物種: Hepatitis C virus
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion (By similarity). Envelope glycoprotein E1: Virion membrane; Single-pass type I membrane protein (Potential). Envelope glycoprotein E2: Virion membrane; Single-pass type I membrane protein (Potential). p7: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Protease NS2-3: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 5A: Host endoplasmic reticulum membrane; Peripheral membrane protein (By similarity). RNA-directed RNA polymerase: Host endoplasmic reticulum membrane; Single-pass type I membrane protein (Potential): P26663
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 64633.01

構造登録者

Li, H.,Love, R.L. (登録日: 2006-06-12, 公開日: 2006-09-05, 最終更新日: 2024-04-03)

• 主引用文献: Li, H.,Tatlock, J.,Linton, A.,Gonzalez, J.,Borchardt, A.,Dragovich, P.,Jewell, T.,Prins, T.,Zhou, R.,Blazel, J.,Parge, H.,Love, R.,Hickey, M.,Doan, C.,Shi, S.,Duggal, R.,Lewis, C.,Fuhrman, S.; Identification and structure-based optimization of novel dihydropyrones as potent HCV RNA polymerase inhibitors.; Bioorg.Med.Chem.Lett., 16:4834-4838, 2006; PubMed: 16824756; DOI: 10.1016/j.bmcl.2006.06.065

実験手法

X-RAY DIFFRACTION (1.58 Å)