2HAI

Crystal structure of HCV NS5B RNA polymerase in complex with novel class of dihydropyrone-containing inhibitor.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003723	molecular_function	RNA binding
A	0003968	molecular_function	RNA-dependent RNA polymerase activity
A	0039694	biological_process	viral RNA genome replication

Functional Information from PDB Data

site_id	AC1
Number of Residues	12
Details	BINDING SITE FOR RESIDUE PFI A 601

Chain	Residue
A	LEU419
A	HOH641
A	HOH653
A	HOH1091
A	ARG422
A	MET423
A	HIS475
A	SER476
A	ILE482
A	ALA486
A	LEU497
A	ARG501

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	BINDING: BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572

Chain	Residue	Details
A	THR221
A	ASP319
A	LEU320

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by serine protease/helicase NS3 => ECO:0000250|UniProtKB:P27958

Chain	Residue	Details
A	SER1

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site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: Phosphoserine; by host => ECO:0000250|UniProtKB:P26662

Chain	Residue	Details
A	LEU30
A	ARG43

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