2HAH

The structure of FIV 12S protease in complex with TL-3

2HAH の概要

• エントリーDOI: 10.2210/pdb2hah/pdb
• 関連するPDBエントリー: 2AZ8 5FIV
• 関連するBIRD辞書のPRD_ID: PRD_000434
• 分子名称: Protease, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate (3 entities in total)
• 機能のキーワード: retroviral, protease, aspartyl, feline, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Feline immunodeficiency virus (isolate Petaluma)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14135.30

構造登録者

Heaslet, H.,Lin, Y.C.,Elder, J.H.,Stout, C.D. (登録日: 2006-06-12, 公開日: 2007-02-13, 最終更新日: 2023-08-30)

• 主引用文献: Heaslet, H.,Lin, Y.C.,Tam, K.,Torbett, B.E.,Elder, J.H.,Stout, C.D.; Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3.; Retrovirology, 4:1-1, 2007; PubMed: 17212810; DOI: 10.1186/1742-4690-4-1

実験手法

X-RAY DIFFRACTION (1.7 Å)